QUANTIFICAÇÃO DE IMUNOGLOBULINA ANTI-HBS EM ESTUDANTES DA SAÚDE PREVIAMENTE VACINADOS CONTRA HBV
QUANTIFICATION OF ANTI-HBS IMMUNOGLOBULIN IN HEALTH STUDENTS PREVIOUSLY VACCINATED AGAINST HBV
DOI:
https://doi.org/10.18066/revistaunivap.v30i68.4540
Abstract
It is estimated that 257 million people worldwide are infected with the hepatitis B virus (HBV). University students in the health field, due to their academic activities and future professions, are in a high-risk group. Vaccination against the virus is considered the most effective prophylactic method, and the state of immunity is characterized by the presence of immunoglobulin against the virus's surface antigen (HBsAg). This study aimed to assess the immunity status of 20 properly vaccinated undergraduate health students through the comparison of qualitative and quantitative methodologies. This study demonstrated that although all students had completed their vaccination schedules, 12 (60%) did not exhibit protective levels of antibodies, and discrepancies between methodologies indicated that rapid tests should not be used as the sole method for establishing a diagnosis
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References
Abich, D. R., De Lima, G. C. S., Lissarassa, Y. P. S., Mallet, E. K. V., & Comparsi, B. (2016). Imunização contra o vírus da Hepatite B em estudantes da área da saúde. Revista contexto & saúde, 16(30), 77-84. http://dx.doi.org/ 10.21527/2176-7114.2016.30.77-84
Cruz, H. M. (2014). Avaliação do desempenho de testes rápidos na detecção de marcadores do vírus da hepatite B.(Dissertação de Mestrado em Medicina Tropical) - Fundação Oswaldo Cruz, Instituto Oswaldo Cruz). https://www.arca.fiocruz.br/handle/icict/12119
Damiot, A., Pinto, A. J., Turner, J. E., & Gualano, B. (2020). Immunological implications of physical inactivity among older adults during the COVID-19 pandemic. Gerontology, 66(5), 431-438. https://doi.org/10.1159/000509216
Das, S., Ramakrishnan, K., Behera, S. K., Ganesapandian, M., Xavier, A. S., & Selvarajan, S. (2019). Hepatitis B vaccine and immunoglobulin: key concepts. Journal of clinical and translational hepatology, 7(2), 165. https://doi.org/10.14218/jcth.2018.00037
Duarte, G., Pezzuto, P., Barros, T. D., Mosimann Junior, G., & Martínez-Espinosa, F. E. (2021). Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: hepatites virais. Epidemiologia e Serviços de Saúde, 30, e2020834. https://doi.org/10.1590/s1679-4974202100016.esp1
Ferreira, C. T., & Silveira, T. R. D. (2006). Prevenção das hepatites virais através de imunização. Jornal de Pediatria, 82, s55-s66. https://doi.org/10.1590/s0021-75572006000400007
Harris, A. (2024). Hepatitis B. CDC Yellow Book 2024. https://wwwnc.cdc.gov/travel/yellowbook/2024/infections-diseases/hepatitis-b
He, F., Ma, Y. J., Zhou, T. Y., Duan, J. C., Wang, J. F., Ji, Y. L., Li, H., Zhang, J., & Tang, H. (2016). The serum anti-HBs level among children who received routine hepatitis B vaccination during infancy in Mianyang City, China: a cross-sectional study. Viral immunology, 29(1), 40-48. https://doi.org/10.1089/vim.2015.0073
Lu, C. Y., Chiang, B. L., Chi, W. K., Chang, M. H., Ni, Y. H., Hsu, H. M., Twu, S‐J., Su, I‐J., Huang, L‐M., & Lee, C. Y. (2004). Waning Immunity To Plasma–Derived Hepatitis B Vaccine and the Need for Boosters 15 Years After Neonatal Vaccination. Hepatology, 40(6), 1415-1420.
Martins, R. M., Bensabath, G., Arraes, L. C., Barbosa, G. G., Aguiar Oliveira, M. D. L., & Bastos Camacho, L. A. (2003). Estudo multicêntrico de imunogenicidade e reatogenicidade de vacinas contra hepatite B: informe preliminar. Epidemiologia e Serviços de Saúde, 12(3), 165-166.
McMahon, B. J., Bruden, D. L., Petersen, K. M., Bulkow, L. R., Parkinson, A. J., Nainan, O., Khristova, M. L., Zanis, C., Peters, H., & Margolis, H. S. (2005). Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-up. Annals of internal medicine, 142(5), 333-341.
Ministério da Saúde. (2023). Portaria SECTICS/MS Nº 25, de 18 de maio de 2023. Torna pública a decisão de atualizar, no âmbito do Sistema Único de Saúde - SUS, o Protocolo Clínico e Diretrizes Terapêuticas de Hepatite B e Coinfecções.
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013). Causes, consequences, and reversal of immune system aging. The Journal of clinical investigation, 123(3), 958-965.
Moraes, J. C. D., Luna, E. J. D. A., & Grimaldi, R. A. (2010). Imunogenicidade da vacina brasileira contra hepatite B em adultos. Revista de Saúde Pública, 44, 353-359.
Pinheiro, J., & Zeitoune, R. C. G. (2008). Hepatite B: conhecimento e medidas de biossegurança e a saúde do trabalhador de enfermagem. Escola Anna Nery, 12, 258-264.
Pinto, A. C. S., de Almeida, M. I., & da Costa Pinheiro, P. N. (2011). Análise da susceptibilidade às doenças imunopreveníveis em profissionais de saúde a partir do status vacinal. Rev Rene, 12(1), 11.
Poiteau, L., Soulier, A., Roudot-Thoraval, F., Hézode, C., Challine, D., Pawlotsky, J. M., & Chevaliez, S. (2017). Performance of rapid diagnostic tests for the detection of anti-HBs in various patient populations. Journal of Clinical Virology, 96, 64-66.
Powell, A. E., & Leon, M. A. (1970). Reversible interaction of human lymphocytes with the mitogen concanavalin A. Experimental cell research, 62(2-3), 315-325.
Souza, F. D. O., & Araújo, T. M. D. (2018). Exposição ocupacional e vacinação para hepatite B entre trabalhadores da atenção primária e média complexidade. Revista Brasileira de Medicina do Trabalho, 16(1), 36-43.
Sande, M. V. D., Waight, P., Mendy, M., Rayco-Solon, P., Hutt, P., Fulford, T., Doherty, C., McConkey, S., Jeffries, D., Hall, A. J., & Whittle, H. C. (2006). Long-term protection against carriage of hepatitis B virus after infant vaccination. The Journal of Infectious Diseases, 193(11), 1528-1535.
World Health Organization. (2017). WHO guidelines on hepatitis B and C testing. World Health Organization.
Zannolli, R., & Morgese, G. (1997). Hepatitis B vaccine: current issues. Annals of Pharmacotherapy, 31(9), 1059-1067.
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2024-12-11
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Abrahão Trindade de Lima, G., Osorio Cesar Doria, A. C. ., & Canettieri , A. C. V. (2024). QUANTIFICATION OF ANTI-HBS IMMUNOGLOBULIN IN HEALTH STUDENTS PREVIOUSLY VACCINATED AGAINST HBV. Revista Univap, 30(68). https://doi.org/10.18066/revistaunivap.v30i68.4540
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Copyright (c) 2024 Revista Univap
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International.
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http://creativecommons.org/licenses/by/4.0/legalcode
DOI:
https://doi.org/10.18066/revistaunivap.v30i68.4540Abstract
It is estimated that 257 million people worldwide are infected with the hepatitis B virus (HBV). University students in the health field, due to their academic activities and future professions, are in a high-risk group. Vaccination against the virus is considered the most effective prophylactic method, and the state of immunity is characterized by the presence of immunoglobulin against the virus's surface antigen (HBsAg). This study aimed to assess the immunity status of 20 properly vaccinated undergraduate health students through the comparison of qualitative and quantitative methodologies. This study demonstrated that although all students had completed their vaccination schedules, 12 (60%) did not exhibit protective levels of antibodies, and discrepancies between methodologies indicated that rapid tests should not be used as the sole method for establishing a diagnosis
Downloads
References
Abich, D. R., De Lima, G. C. S., Lissarassa, Y. P. S., Mallet, E. K. V., & Comparsi, B. (2016). Imunização contra o vírus da Hepatite B em estudantes da área da saúde. Revista contexto & saúde, 16(30), 77-84. http://dx.doi.org/ 10.21527/2176-7114.2016.30.77-84
Cruz, H. M. (2014). Avaliação do desempenho de testes rápidos na detecção de marcadores do vírus da hepatite B.(Dissertação de Mestrado em Medicina Tropical) - Fundação Oswaldo Cruz, Instituto Oswaldo Cruz). https://www.arca.fiocruz.br/handle/icict/12119
Damiot, A., Pinto, A. J., Turner, J. E., & Gualano, B. (2020). Immunological implications of physical inactivity among older adults during the COVID-19 pandemic. Gerontology, 66(5), 431-438. https://doi.org/10.1159/000509216
Das, S., Ramakrishnan, K., Behera, S. K., Ganesapandian, M., Xavier, A. S., & Selvarajan, S. (2019). Hepatitis B vaccine and immunoglobulin: key concepts. Journal of clinical and translational hepatology, 7(2), 165. https://doi.org/10.14218/jcth.2018.00037
Duarte, G., Pezzuto, P., Barros, T. D., Mosimann Junior, G., & Martínez-Espinosa, F. E. (2021). Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: hepatites virais. Epidemiologia e Serviços de Saúde, 30, e2020834. https://doi.org/10.1590/s1679-4974202100016.esp1
Ferreira, C. T., & Silveira, T. R. D. (2006). Prevenção das hepatites virais através de imunização. Jornal de Pediatria, 82, s55-s66. https://doi.org/10.1590/s0021-75572006000400007
Harris, A. (2024). Hepatitis B. CDC Yellow Book 2024. https://wwwnc.cdc.gov/travel/yellowbook/2024/infections-diseases/hepatitis-b
He, F., Ma, Y. J., Zhou, T. Y., Duan, J. C., Wang, J. F., Ji, Y. L., Li, H., Zhang, J., & Tang, H. (2016). The serum anti-HBs level among children who received routine hepatitis B vaccination during infancy in Mianyang City, China: a cross-sectional study. Viral immunology, 29(1), 40-48. https://doi.org/10.1089/vim.2015.0073
Lu, C. Y., Chiang, B. L., Chi, W. K., Chang, M. H., Ni, Y. H., Hsu, H. M., Twu, S‐J., Su, I‐J., Huang, L‐M., & Lee, C. Y. (2004). Waning Immunity To Plasma–Derived Hepatitis B Vaccine and the Need for Boosters 15 Years After Neonatal Vaccination. Hepatology, 40(6), 1415-1420.
Martins, R. M., Bensabath, G., Arraes, L. C., Barbosa, G. G., Aguiar Oliveira, M. D. L., & Bastos Camacho, L. A. (2003). Estudo multicêntrico de imunogenicidade e reatogenicidade de vacinas contra hepatite B: informe preliminar. Epidemiologia e Serviços de Saúde, 12(3), 165-166.
McMahon, B. J., Bruden, D. L., Petersen, K. M., Bulkow, L. R., Parkinson, A. J., Nainan, O., Khristova, M. L., Zanis, C., Peters, H., & Margolis, H. S. (2005). Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-up. Annals of internal medicine, 142(5), 333-341.
Ministério da Saúde. (2023). Portaria SECTICS/MS Nº 25, de 18 de maio de 2023. Torna pública a decisão de atualizar, no âmbito do Sistema Único de Saúde - SUS, o Protocolo Clínico e Diretrizes Terapêuticas de Hepatite B e Coinfecções.
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013). Causes, consequences, and reversal of immune system aging. The Journal of clinical investigation, 123(3), 958-965.
Moraes, J. C. D., Luna, E. J. D. A., & Grimaldi, R. A. (2010). Imunogenicidade da vacina brasileira contra hepatite B em adultos. Revista de Saúde Pública, 44, 353-359.
Pinheiro, J., & Zeitoune, R. C. G. (2008). Hepatite B: conhecimento e medidas de biossegurança e a saúde do trabalhador de enfermagem. Escola Anna Nery, 12, 258-264.
Pinto, A. C. S., de Almeida, M. I., & da Costa Pinheiro, P. N. (2011). Análise da susceptibilidade às doenças imunopreveníveis em profissionais de saúde a partir do status vacinal. Rev Rene, 12(1), 11.
Poiteau, L., Soulier, A., Roudot-Thoraval, F., Hézode, C., Challine, D., Pawlotsky, J. M., & Chevaliez, S. (2017). Performance of rapid diagnostic tests for the detection of anti-HBs in various patient populations. Journal of Clinical Virology, 96, 64-66.
Powell, A. E., & Leon, M. A. (1970). Reversible interaction of human lymphocytes with the mitogen concanavalin A. Experimental cell research, 62(2-3), 315-325.
Souza, F. D. O., & Araújo, T. M. D. (2018). Exposição ocupacional e vacinação para hepatite B entre trabalhadores da atenção primária e média complexidade. Revista Brasileira de Medicina do Trabalho, 16(1), 36-43.
Sande, M. V. D., Waight, P., Mendy, M., Rayco-Solon, P., Hutt, P., Fulford, T., Doherty, C., McConkey, S., Jeffries, D., Hall, A. J., & Whittle, H. C. (2006). Long-term protection against carriage of hepatitis B virus after infant vaccination. The Journal of Infectious Diseases, 193(11), 1528-1535.
World Health Organization. (2017). WHO guidelines on hepatitis B and C testing. World Health Organization.
Zannolli, R., & Morgese, G. (1997). Hepatitis B vaccine: current issues. Annals of Pharmacotherapy, 31(9), 1059-1067.
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This license allows others to distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation.
http://creativecommons.org/licenses/by/4.0/legalcode
