GENE SERPINA1: POTENCIAL MARCADOR DIAGNÓSTICO EM CARCINOMAS PAPILÍFEROS DA TIREOIDE

Autores

  • Joyce Nascimento Santos Universidade do Vale do Paraíba - UNIVAP
  • João Paulo da Silva Queiroz Universidade do Vale do Paraíba - UNIVAP
  • Lázaro Pinto Medeiros Neto Universidade do Vale do Paraíba - UNIVAP
  • André Bandiera de Oliveira Santos Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
  • Renata de Azevedo Canevari Universidade do Vale do Paraíba - UNIVAP

DOI:

https://doi.org/10.18066/revistaunivap.v27i56.2578

Palavras-chave:

Carcinoma da tireoide, diagnóstico, marcador molecular, expressão gênica, SERPINA1.

Resumo

As neoplasias tireoidianas são o principal tipo de malignidade endócrina, sendo atualmente consideradas um problema de saúde pública com aumento constante em sua incidência nos últimos anos. A descoberta de marcadores moleculares que possam ser aplicados na rotina clínica em conjunto com a biópsia por aspiração com agulha fina (PAAF) pode propiciar um diagnóstico mais preciso e consequentemente um tratamento mais eficiente para o paciente. O objetivo desse estudo foi avaliar se o gene SERPINA1 pode ser considerado um marcador diagnóstico em carcinomas de tireoide. Foi realizada a análise de expressão gênica pela RT-qPCR, em 32 amostras de tecido tireoidiano, sendo 13 bócios, 11 carcinomas papilíferos, quatro carcinomas foliculares e quatro tecidos não tumorais de tireoide. A expressão aumentada do gene SERPINA1 foi observada nas amostras de carcinoma papilífero em comparação com amostras de bócio (P=0.0319) e com as amostras de carcinoma folicular (P=0.0430). Não foi observada expressão diferencial significativa entre amostras de carcinoma folicular com as amostras de bócio (P= 0.5329). Os resultados da análise de expressão gênica sugerem que o gene SERPINA1 pode ser considerado um marcador diagnóstico em carcinomas papilíferos de tireoide.

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Publicado

2021-10-26

Como Citar

Santos, J. N., Queiroz, J. P. da S., Medeiros Neto, L. P., Santos, A. B. de O., & Canevari, R. de A. (2021). GENE SERPINA1: POTENCIAL MARCADOR DIAGNÓSTICO EM CARCINOMAS PAPILÍFEROS DA TIREOIDE. Revista Univap, 27(56). https://doi.org/10.18066/revistaunivap.v27i56.2578