BUSCA DE MARCADORES MOLECULARES PREDITIVOS DO ACOMETIMENTO DE LINFONODOS EM CARCINOMAS PAPILÍFEROS DE TIREOIDE

Autores

DOI:

https://doi.org/10.18066/revistaunivap.v28i59.4350

Palavras-chave:

Câncer de tireoide, Linfonodo, Expressão gênica, Marcador molecular

Resumo

O câncer de tireoide é a neoplasia que mais cresce em incidência todos os anos, sendo o carcinoma papilífero de tireoide (CPT) o subtipo mais comum. Em muitos casos estes tumores podem se tornar agressivos, ocasionando metástases linfonodais. A determinação de marcadores moleculares pela análise de expressão gênica é uma importante ferramenta para a determinação do prognóstico destes tumores. Considerando o papel dos genes NEDD9, B3GNT7, PHB, BAD, PAXIP1, PPM1D e PIK3R5 na etiologia de diversos cânceres, este estudo consistiu em verificar pela técnica de RT-qPCR se os mesmos podem ser marcadores moleculares preditivos do acometimento de linfonodos e se estão relacionados ao desenvolvimento destes tumores. No presente estudo não foi observada expressão diferencial significativa dos genes analisados entre os grupos amostrais de CPT versus MCPT (microcarcinomas) e entre os grupos de CPT linfonodo positivo versus CPT linfonodo negativo, indicando que estes genes não estão relacionados ao desenvolvimento tumoral e não podem ser considerados marcadores preditivos de metástases em linfonodos em CPT.

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Biografia do Autor

Maria Luiza Lopes de Oliveira, Universidade do Vale do Paraíba - UNIVAP

Estudante do último ano de Biomedicina, Iniciante Científica do laboratório de Biologia Molecular do Câncer

João Vitor Alcântara da Costa, Universidade do Vale do Paraíba - UNIVAP

Estudante do último ano de Biomedicina, Iniciante Científico do laboratório de Biologia Molecular do Câncer.

Luana Araujo da Silva , Universidade do Vale do Paraíba - UNIVAP

Estudante do último ano de Biomedicina, Iniciante Científica do laboratório de Biologia Molecular do Câncer

Joyce Nascimento Santos

Biomédica (2019). Habilitada em Análises clínica e Biologia molecular.

Renata de Azevedo Canevari, Universidade do Vale do Paraíba - UNIVAP

Coordenadora do Laboratório de Biologia Molecular do Câncer
Coordenadora do Programa de Pós Graduação em Engenharia Biomédica - Mestrado
Instituto de Pesquisa e Desenvolvimento - IP&D
Universidade do Vale do Paraíba - UNIVAP

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Publicado

2022-06-30

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Lopes de Oliveira, M. L. ., Alcântara da Costa, J. V., Araujo da Silva , L. ., Santos , J. N., & de Azevedo Canevari, R. . (2022). BUSCA DE MARCADORES MOLECULARES PREDITIVOS DO ACOMETIMENTO DE LINFONODOS EM CARCINOMAS PAPILÍFEROS DE TIREOIDE. Revista Univap, 28(59). https://doi.org/10.18066/revistaunivap.v28i59.4350

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