EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS

Autores

  • Marco Antonio Vieira Grinet Universidade do Vale do Paraiba
  • Thiago Moreira Pedroso Engenharia Biomédica/Universidade do Vale do Paraíba
  • Fernanda Roberta Marciano Engenharia Biomédica/Universidade do Vale do Paraíba

DOI:

https://doi.org/10.18066/revistaunivap.v22i40.1680

Palavras-chave:

Cell Culture, gMSC, Bone Matrix, Hydrogel, Cell Encaps

Resumo

An in vitro encapsulation platform utilizing hydrogels and bone matrix (BM) scaffolds to investigate the effects of microenvironmental parameters on encapsulated goat mesenchymal stem cells (gMSC) was presented. The base encapsulation matrix was composed of a biocompatible hydrogel formed through a photoinitiated polymerization process. Different polymer concentrations were used to compare the effects of hydrogel crosslinking density on physical properties, as well as on cell viability. The potential of BM to support the growth and differentiation of gMSC was also analyzed. Both methods were compared in order to analyze viability. Structures that better allow flow of oxygen showed more promising results, whereas BM structures require a better evaluation method for concrete results.

Downloads

Não há dados estatísticos.

Downloads

Publicado

2017-01-09

Como Citar

Grinet, M. A. V., Pedroso, T. M., & Marciano, F. R. (2017). EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS. Revista Univap, 22(40), 253. https://doi.org/10.18066/revistaunivap.v22i40.1680