EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
DOI:
https://doi.org/10.18066/revistaunivap.v22i40.1680
Abstract
An in vitro encapsulation platform utilizing hydrogels and bone matrix (BM) scaffolds to investigate the effects of microenvironmental parameters on encapsulated goat mesenchymal stem cells (gMSC) was presented. The base encapsulation matrix was composed of a biocompatible hydrogel formed through a photoinitiated polymerization process. Different polymer concentrations were used to compare the effects of hydrogel crosslinking density on physical properties, as well as on cell viability. The potential of BM to support the growth and differentiation of gMSC was also analyzed. Both methods were compared in order to analyze viability. Structures that better allow flow of oxygen showed more promising results, whereas BM structures require a better evaluation method for concrete results.
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Published
2017-01-09
How to Cite
Grinet, M. A. V., Pedroso, T. M., & Marciano, F. R. (2017). EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS. Revista Univap, 22(40), 253. https://doi.org/10.18066/revistaunivap.v22i40.1680
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Resumo - INIC
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This work is licensed under a Creative Commons Attribution 4.0 International.
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DOI:
https://doi.org/10.18066/revistaunivap.v22i40.1680Abstract
An in vitro encapsulation platform utilizing hydrogels and bone matrix (BM) scaffolds to investigate the effects of microenvironmental parameters on encapsulated goat mesenchymal stem cells (gMSC) was presented. The base encapsulation matrix was composed of a biocompatible hydrogel formed through a photoinitiated polymerization process. Different polymer concentrations were used to compare the effects of hydrogel crosslinking density on physical properties, as well as on cell viability. The potential of BM to support the growth and differentiation of gMSC was also analyzed. Both methods were compared in order to analyze viability. Structures that better allow flow of oxygen showed more promising results, whereas BM structures require a better evaluation method for concrete results.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International.
This license allows others to distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation.
http://creativecommons.org/licenses/by/4.0/legalcode
