BUSCA DE MARCADORES MOLECULARES PREDITIVOS DO ACOMETIMENTO DE LINFONODOS EM CARCINOMAS PAPILÍFEROS DE TIREOIDE
MOLECULAR MARKERS PREDICTIVE OF LYMPH NODE INVOLVEMENT IN PAPILLARY THYROID CARCINOMAS
DOI:
https://doi.org/10.18066/revistaunivap.v28i59.4350
Resumo
O câncer de tireoide é a neoplasia que mais cresce em incidência todos os anos, sendo o carcinoma papilífero de tireoide (CPT) o subtipo mais comum. Em muitos casos estes tumores podem se tornar agressivos, ocasionando metástases linfonodais. A determinação de marcadores moleculares pela análise de expressão gênica é uma importante ferramenta para a determinação do prognóstico destes tumores. Considerando o papel dos genes NEDD9, B3GNT7, PHB, BAD, PAXIP1, PPM1D e PIK3R5 na etiologia de diversos cânceres, este estudo consistiu em verificar pela técnica de RT-qPCR se os mesmos podem ser marcadores moleculares preditivos do acometimento de linfonodos e se estão relacionados ao desenvolvimento destes tumores. No presente estudo não foi observada expressão diferencial significativa dos genes analisados entre os grupos amostrais de CPT versus MCPT (microcarcinomas) e entre os grupos de CPT linfonodo positivo versus CPT linfonodo negativo, indicando que estes genes não estão relacionados ao desenvolvimento tumoral e não podem ser considerados marcadores preditivos de metástases em linfonodos em CPT.
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Referências
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Bumbat, M., Wang, M., Liang, W., Ye, P., Sun, W., & Liu, B. (2020). Effects of Me2SO and trehalose on the cell viability, proliferation, and Bcl-2 family gene (BCL-2, BAX, and BAD) expression in cryopreserved human breast cancer cells. Biopreservation and Biobanking, 18(1), 33-40.
Canevari, R. A., Marchi, F. A., Domingues, M. A., de Andrade, V. P., Caldeira, J. R., Verjovski-Almeida, S., Rogatto, S. R. & Reis, E. M. (2016). Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma. Tumor Biology, 37(10), 13855-13870.
Chen, B., Lu, X., Zhou, Q., Chen, Q., Zhu, S., Liu, H., & Li, G. (2021). LncRNA PAXIP1-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Ovarian Cancer. Research Square, 12. DOI=10.3389/fgene.2021.697471
Chen, J. V., Morgan, T. A., Liu, C., Khanafshar, E., & Choi, H. H. (2022). Cervical Lymph Node Features Predictive of Suboptimal Adequacy During Ultrasound‐Guided Fine‐Needle Aspiration in Thyroid Cancer Patients. Journal of Ultrasound in Medicine, 41(1), 135-145.
Da Silva, R. M., Pupin, B., Bhattacharjee, T. T., Kulcsar, M. A. V., Uno, M., Chammas, R., & de Azevedo Canevari, R. (2020). ATR-FTIR spectroscopy and CDKN1C gene expression in the prediction of lymph nodes metastases in papillary thyroid carcinoma. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 228, 117693.
De Gregoriis, G., Ramos, J. A., Fernandes, P. V., Vignal, G. M., Brianese, R. C., Carraro, D. M., Monteiro, A. N., Struchiner, C. J., Suarez-Kurtz, G., Vianna-Jorge, R. & de Carvalho, M. A. (2017). DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis. Cancer biology & therapy, 18(6), 439-449.
Dehghan, M. H., Hedayati, M., Shivaee, S., Shakib, H., & Rajabi, S. (2021). Tamoxifen triggers apoptosis of papillary thyroid cancer cells by two different mechanisms. Gene Reports, 24, 101266.
Deneka, A. Y., Kopp, M. C., Nikonova, A. S., Gaponova, A. V., Kiseleva, A. A., Hensley, H. H., Flieder, D. B., Serebriiskii, I. G., & Golemis, E. A. (2021). Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer. Cancer research, 81(13), 3717-3726.
Deng, W., Li, J., Dorrah, K., Jimenez-Tapia, D., Arriaga, B., Hao, Q., Cao, W., Gao, Z., Vadgama, J. & Wu, Y. (2020). The role of PPM1D in cancer and advances in studies of its inhibitors. Biomedicine & Pharmacotherapy, 125, 109956.
Fang, C. H., Lin, Y. T., Liang, C. M., & Liang, S. M. (2020). A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3 - PBX1 and β-catenin - ABCG2 signaling. Journal of Biomedical Science, 27(1), 1-18.
Hejaz, H. A., Abuzaina, I., Aldeen, R. N., & Saad, S. (2022). Currently Used and New Molecular Markers for Thyroid Cancer Diagnosis. Middle East Journal of Cancer, 13(2), 193-215.
Hua, S., Feng, T., Yin, L., Wang, Q., & Shao, X. (2021). NEDD9 overexpression: Prognostic and guidance value in acute myeloid leukaemia. Journal of cellular and molecular medicine, 25(19), 9331-9339.
Jhuraney, A., Woods, N. T., Wright, G., Rix, L., Kinose, F., Kroeger, J. L., Remily-Wood, E., Cress, W. D., Koomen, J. M., Brantley, S. G., Gray, J. E., Haura, E. B., Rix, U. & Monteiro, A. N. (2016). PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung CancerPAXIP1 Potentiates WEE1 Inhibitor Action. Molecular cancer therapeutics, 15(7), 1669-1681.
Joo, L., Na, D., Kim, J., & Seo, H. (2022). Comparison of Core Needle Biopsy and Repeat Fine-Needle Aspiration in Avoiding Diagnostic Surgery for Thyroid Nodules Initially Diagnosed as Atypia/Follicular Lesion of Undetermined Significance. Korean Journal of Radiology, 23(2), 280-288.
Kim, J., Kim, M., Choi, S., Choi, S., Choi, H., Lee, C., Kang, S.‐W., Lee, J., Jeong, J. J., Nam, K.‐H. & Chung, W. (2020). Cystic Lateral Lymph Node Metastases From Papillary Thyroid Cancer Patients. The Laryngoscope, 130(12), E976-E981.
Li, L., Kim, H., Park, S., Lee, S., Kim, L., Lee, J., Kim, S., Kim, Y. T., Kim, S. W. & Nam, E. (2019). Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer. Cancer Research and Treatment, 51(3), 1117-1127.
Leiphrakpam, P. D., Patil, P. P., Remmers, N., Swanson, B., Grandgenett, P. M., Qiu, F., Yu, F. & Radhakrishnan, P. (2019). Role of keratan sulfate expression in human pancreatic cancer malignancy. Scientific reports, 9(1), 1-10.
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Liu, P., Xu, Y., Zhang, W., Li, Y., Tang, L., Chen, W., Sun, Q. & Guan, X. (2017). Prohibitin promotes androgen receptor activation in ER-positive breast cancer. Cell cycle, 16(8), 776-784.
Liu, T., Zhou, S., Yu, J., Guo, Y., Wang, Y., Zhou, J., & Chang, C. (2019). Prediction of lymph node metastasis in patients with papillary thyroid carcinoma: a radiomics method based on preoperative ultrasound images. Technology in cancer research & treatment, 18, 1533033819831713.
Liu, Y., Jing, X. B., Wang, Z. C., & Han, Q. K. (2021). HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression. Human genomics, 15(1), 1-10.
Lu, C. H., Wu, W. Y., Lai, Y. J., Yang, C. M., & Yu, L. C. (2014). Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. Glycobiology, 24(4), 359-367.
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2022-06-30
Como Citar
Lopes de Oliveira, M. L. ., Alcântara da Costa, J. V., Araujo da Silva , L. ., Santos , J. N., & de Azevedo Canevari, R. . (2022). BUSCA DE MARCADORES MOLECULARES PREDITIVOS DO ACOMETIMENTO DE LINFONODOS EM CARCINOMAS PAPILÍFEROS DE TIREOIDE. Revista Univap, 28(59). https://doi.org/10.18066/revistaunivap.v28i59.4350
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Copyright (c) 2022 Revista Univap
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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DOI:
https://doi.org/10.18066/revistaunivap.v28i59.4350Resumo
O câncer de tireoide é a neoplasia que mais cresce em incidência todos os anos, sendo o carcinoma papilífero de tireoide (CPT) o subtipo mais comum. Em muitos casos estes tumores podem se tornar agressivos, ocasionando metástases linfonodais. A determinação de marcadores moleculares pela análise de expressão gênica é uma importante ferramenta para a determinação do prognóstico destes tumores. Considerando o papel dos genes NEDD9, B3GNT7, PHB, BAD, PAXIP1, PPM1D e PIK3R5 na etiologia de diversos cânceres, este estudo consistiu em verificar pela técnica de RT-qPCR se os mesmos podem ser marcadores moleculares preditivos do acometimento de linfonodos e se estão relacionados ao desenvolvimento destes tumores. No presente estudo não foi observada expressão diferencial significativa dos genes analisados entre os grupos amostrais de CPT versus MCPT (microcarcinomas) e entre os grupos de CPT linfonodo positivo versus CPT linfonodo negativo, indicando que estes genes não estão relacionados ao desenvolvimento tumoral e não podem ser considerados marcadores preditivos de metástases em linfonodos em CPT.
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Referências
Barbier-Torres, L. & Lu, S. C. (2020). Prohibitin 1 in liver injury and cancer. Experimental Biology and Medicine, 245( 5), 385–394.
Bemmerlein, L., Deniz, I. A., Karbanová, J., Jacobi, A., Drukewitz, S., Link, T., Göbel, A., Sevenich, L., Taubenberger, A. V., Wimberger, P., Kuhlmann, J. D. & Corbeil, D. (2022). Decoding Single Cell Morphology in Osteotropic Breast Cancer Cells for Dissecting Their Migratory, Molecular and Biophysical Heterogeneity. Cancers, 14(3), 603.
Borges, F. A., Camilo-Júnior, D. J., Yamamoto, F. M., & Xavier-Júnior, J. C. C. (2022). Thyroid FNA performed by cytopathologists accompanied by radiologists guiding the ultrasound provide high-level quality results: A retrospective observational study. Annals of Diagnostic Pathology, 58, 151912
Bumbat, M., Wang, M., Liang, W., Ye, P., Sun, W., & Liu, B. (2020). Effects of Me2SO and trehalose on the cell viability, proliferation, and Bcl-2 family gene (BCL-2, BAX, and BAD) expression in cryopreserved human breast cancer cells. Biopreservation and Biobanking, 18(1), 33-40.
Canevari, R. A., Marchi, F. A., Domingues, M. A., de Andrade, V. P., Caldeira, J. R., Verjovski-Almeida, S., Rogatto, S. R. & Reis, E. M. (2016). Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma. Tumor Biology, 37(10), 13855-13870.
Chen, B., Lu, X., Zhou, Q., Chen, Q., Zhu, S., Liu, H., & Li, G. (2021). LncRNA PAXIP1-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Ovarian Cancer. Research Square, 12. DOI=10.3389/fgene.2021.697471
Chen, J. V., Morgan, T. A., Liu, C., Khanafshar, E., & Choi, H. H. (2022). Cervical Lymph Node Features Predictive of Suboptimal Adequacy During Ultrasound‐Guided Fine‐Needle Aspiration in Thyroid Cancer Patients. Journal of Ultrasound in Medicine, 41(1), 135-145.
Da Silva, R. M., Pupin, B., Bhattacharjee, T. T., Kulcsar, M. A. V., Uno, M., Chammas, R., & de Azevedo Canevari, R. (2020). ATR-FTIR spectroscopy and CDKN1C gene expression in the prediction of lymph nodes metastases in papillary thyroid carcinoma. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 228, 117693.
De Gregoriis, G., Ramos, J. A., Fernandes, P. V., Vignal, G. M., Brianese, R. C., Carraro, D. M., Monteiro, A. N., Struchiner, C. J., Suarez-Kurtz, G., Vianna-Jorge, R. & de Carvalho, M. A. (2017). DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis. Cancer biology & therapy, 18(6), 439-449.
Dehghan, M. H., Hedayati, M., Shivaee, S., Shakib, H., & Rajabi, S. (2021). Tamoxifen triggers apoptosis of papillary thyroid cancer cells by two different mechanisms. Gene Reports, 24, 101266.
Deneka, A. Y., Kopp, M. C., Nikonova, A. S., Gaponova, A. V., Kiseleva, A. A., Hensley, H. H., Flieder, D. B., Serebriiskii, I. G., & Golemis, E. A. (2021). Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer. Cancer research, 81(13), 3717-3726.
Deng, W., Li, J., Dorrah, K., Jimenez-Tapia, D., Arriaga, B., Hao, Q., Cao, W., Gao, Z., Vadgama, J. & Wu, Y. (2020). The role of PPM1D in cancer and advances in studies of its inhibitors. Biomedicine & Pharmacotherapy, 125, 109956.
Fang, C. H., Lin, Y. T., Liang, C. M., & Liang, S. M. (2020). A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3 - PBX1 and β-catenin - ABCG2 signaling. Journal of Biomedical Science, 27(1), 1-18.
Hejaz, H. A., Abuzaina, I., Aldeen, R. N., & Saad, S. (2022). Currently Used and New Molecular Markers for Thyroid Cancer Diagnosis. Middle East Journal of Cancer, 13(2), 193-215.
Hua, S., Feng, T., Yin, L., Wang, Q., & Shao, X. (2021). NEDD9 overexpression: Prognostic and guidance value in acute myeloid leukaemia. Journal of cellular and molecular medicine, 25(19), 9331-9339.
Jhuraney, A., Woods, N. T., Wright, G., Rix, L., Kinose, F., Kroeger, J. L., Remily-Wood, E., Cress, W. D., Koomen, J. M., Brantley, S. G., Gray, J. E., Haura, E. B., Rix, U. & Monteiro, A. N. (2016). PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung CancerPAXIP1 Potentiates WEE1 Inhibitor Action. Molecular cancer therapeutics, 15(7), 1669-1681.
Joo, L., Na, D., Kim, J., & Seo, H. (2022). Comparison of Core Needle Biopsy and Repeat Fine-Needle Aspiration in Avoiding Diagnostic Surgery for Thyroid Nodules Initially Diagnosed as Atypia/Follicular Lesion of Undetermined Significance. Korean Journal of Radiology, 23(2), 280-288.
Kim, J., Kim, M., Choi, S., Choi, S., Choi, H., Lee, C., Kang, S.‐W., Lee, J., Jeong, J. J., Nam, K.‐H. & Chung, W. (2020). Cystic Lateral Lymph Node Metastases From Papillary Thyroid Cancer Patients. The Laryngoscope, 130(12), E976-E981.
Li, L., Kim, H., Park, S., Lee, S., Kim, L., Lee, J., Kim, S., Kim, Y. T., Kim, S. W. & Nam, E. (2019). Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer. Cancer Research and Treatment, 51(3), 1117-1127.
Leiphrakpam, P. D., Patil, P. P., Remmers, N., Swanson, B., Grandgenett, P. M., Qiu, F., Yu, F. & Radhakrishnan, P. (2019). Role of keratan sulfate expression in human pancreatic cancer malignancy. Scientific reports, 9(1), 1-10.
Ledinsky Opačić, I., Gršić, K., Šitić, S., Penavić, I., Pastorčić Grgić, M., & Šarčević, B. (2019). Positive expression of NEDD9 in head and neck cancer is related to better survival period. Acta Clinica Croatica, 58(4.), 655-660.
Liu, P., Xu, Y., Zhang, W., Li, Y., Tang, L., Chen, W., Sun, Q. & Guan, X. (2017). Prohibitin promotes androgen receptor activation in ER-positive breast cancer. Cell cycle, 16(8), 776-784.
Liu, T., Zhou, S., Yu, J., Guo, Y., Wang, Y., Zhou, J., & Chang, C. (2019). Prediction of lymph node metastasis in patients with papillary thyroid carcinoma: a radiomics method based on preoperative ultrasound images. Technology in cancer research & treatment, 18, 1533033819831713.
Liu, Y., Jing, X. B., Wang, Z. C., & Han, Q. K. (2021). HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression. Human genomics, 15(1), 1-10.
Lu, C. H., Wu, W. Y., Lai, Y. J., Yang, C. M., & Yu, L. C. (2014). Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. Glycobiology, 24(4), 359-367.
Lu, Z. W., Wen, D., Wei, W. J., Han, L. T., Xiang, J., Wang, Y. L., Wang, Y., Liao, T. & Ji, Q. H. (2020). Silencing of PPM1D inhibits cell proliferation and invasion through the p38 MAPK and p53 signaling pathway in papillary thyroid carcinoma. Oncology reports, 43(3), 783-794.
Machiela, M. J., Myers, T. A., Lyons, C. J., Koster, R., Figg, W. D., Colli, L. M., Jessop, L., Ahearn, T. U., Freedman, N. D., García-Closas, M. & Chanock, S. J. (2019). Detectible mosaic truncating PPM1D mutations, age and breast cancer risk. Journal of human genetics, 64(6), 545-550.
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